Neuromuscular Blocking Drugs
Pancuronium, Vecuronium, Rocuronium, Tubocurarine
Atracurium, Mivacurium, Cisatracurium,
It is actually two ACh molecules back-to-back.Broken down by Plasma Cholinesterase.
Atracurium = Hofmann elimination and ester hydrolysis (non-specific)
Mivacurium = Short-acting, rapidly hydrolysed by plasma cholinesterase.
Rocuronium is 6-8 times less potent than vecuronium.
These drugs block ACh from binding to the receptor site so end plate potentials don't develop
A metabolite of Hofmann degradation (laudanosine) is a tertiary amine that has epileptogenic properties in high concentration, although this complication has not been reported in humans during general anaesthesia.
They consist of two quaternary ammonium groups joined by a thin chain of methyl groups.
Aminosteroid compounds contain an androstane skeleton to which ACh-like moieties are introduced at the A ring and D ring.
Dr. David Lyness