Bind to and activate cannabinoid receptors, just like THC
Receptors- Transmit information about changing conditions to the inside of the cell, kick-starting the appropriate cellular response.
CB1 & CB2
Targets Cancer cells
Stops cell growth
Doesn't harm normal cells
Cannabis vs Cancer
A 2014 study in Biochemical Pharmacology showed that CBD enhanced the susceptibility of tumor cells to stick to killer white blood cells called lymphokine-activated killer cells, leading to cell destruction. This was accomplished through a sticky protein called intercellular adhesion molecule 1 which increased with CBD. The ICAM-1 molecules on lung cancer cells were already known to decrease their invasiveness and ability to metastasize.
A laboratory study of cannabidiol (CBD) in human glioma cells showed that when given along with chemotherapy, CBD may make chemotherapy more effective and increase cancer cell death without harming normal cells. Studies in mouse models of cancer showed that CBD together with delta-9-THC may make chemotherapy such as temozolomide more effective.
Why is CBD/THC effective against cancer cells?
THC interacts with specific cell surface receptors, like entering a key into lock
This triggers a reaction inside the cell, in cancer cells, these reactions lead to cell death, in normal cells, it doesn’t
Likely due to: Greater number of receptors on the outside of the cancer cells and a different type of reaction inside the cancer cells as compared to the normal cells
Cb1 & Cb2!
Emerging companies like Cannabics are working hard to improve and commercialize Cannabis medicine and treatment as well as pushing for the legalization and acceptance of Cannabinoids
"We are planning to validate the accuracy of our cannabinoid sensitivity tests through a full clinical study once our pre-clinical study is complete" - Dr Eyal Ballan
“I am pleased progress is now being made but very sad for the thousands of people who have died prematurely from treatable cancer because of the lies national governments and the World Health Organization have told about cannabinoids having no medical value, and thus restricting research by placing them in schedule 1.”
-Prof David Nutt
FDA has approved only two drugs containing THC and a synthetic cannabinoid that emulates the activity of THC
The U.S. Food and Drug Administration has not approved Cannabis or cannabinoids for use as a cancer treatment.