Dr. David Lyness
• Hyperventilation ( Kussmaul respirations)
• Shift of oxyhaemoglobin dissociation curve to the right
• Decreases 2,3 DPG levels in red cells, which opposes the effect above.
(Shifts the ODC back to the left) (This effect occurs after 6 hours of acidemia).
• Depression of myocardial contractility (this effect predominates at pH < 7.2 )
• Sympathetic over-activity (tachycardia, vasoconstriction, decreased arrhythmia threshold)
Acidosis is excessive blood acidity caused by an overabundance of acid in the blood or a loss of bicarbonate from the blood (metabolic acidosis), or by a buildup of CO2 in the blood that results from poor lung function or slow breathing (respiratory acidosis).
• Cerebral vasodilation leads to an increase in cerebral blood flow and ICP
(occur in acute respiratory acidosis)
CENTRAL NERVOUS SYSTEM
• Increased bone resorption (chronic metabolic acidosis)
• Shift of K+ out of cells causing hyperkalemia
• Increase in extracellular phosphate concentration
pH 7.35 - 7.45 = NORMAL RANGE
pH <7.35 = Acidosis pH >7.45 = Alkalosis