PHYSICOCHEMICAL PROPERTIES OF IV INDUCTION AGENTS
- Defined as the pH were a drug exists as 50% ionized and 50% unionised.
Imagine your patient is a bucket of water (volume) and you inject a drug into it, it distributes evenly in the bucket.
An acid in an acid solution WILL NOT ionize
An acid in a basic solution WILL ionize
A base in a basic solution WILL NOT ionize
A base in an acid solution WILL ionize
@Gas_CraicDr. David Lyness
and how they influence pharmacokinetics, pharmacodynamics and your patient
Typical adult blood volume is 5 litres.Approximately 77ml/kg