1 Unit of whole blood --> centrifugation & removal of most of the plasma (55% of the total blood volume)
Leaves a unit with a hematocrit of about 60% (volume % of RBC's)
1 PRBC unit will raise the hematocrit of a standard adult patient by 3%.
PRBCs are used when tissue oxygenation is impaired by acute or chronic anaemia.
Contains all factors of the soluble coagulation system
Fibrinogen, II, V, VII, VIII & X Factors In FFP - the most important being factors V & VIII
Used for hypofibrinogenemia, von Willebrand disease, and in situations calling for a "fibrin glue."
Cryo IS NOT just a concentrate of FFP - a unit of cryo contains only 40-50% of the coag factors found in a unit of FFP, but those factors are more concentrated in the cryo (less volume).
Factor VIII 80-150 U with a half-life of 12 hours - this interacts with IX to cause a clot.
von Willebrand factor 100-150 U with a half-life of 24 hours - this travels with factor XIII
Factor XIII 50-75 U with a half-life of 150-300 hours - this improves clot stability
Platelets are stored at room temperature and CANNOT be frozen. They must be used in 5 days.
Platelets (thrombocytes) clump together to form a clot when endothelial damage occurs.
Concentrate is low volume, minimal fuss to make up, easily stored, no cross-match needed and currently expensive... unlicensed in the UK at present, but can be used.
60ml / unit
Dr. David Lyness